China Instrument Network Instrument Research and Development On April 28, 2018, Rongzhi Biotechnology (Qingdao) Co., Ltd. Quantum Quantitative Time-of-Flight Mass Spectrometer “QuanTOF†appraisal meeting was held at Rongzhi Biological Beijing R&D Center. The appraisal committee agreed that the The overall performance of the mass spectrometer has reached the international advanced level and it has passed the appraisal.
Rongzhi Biotechnology (Qingdao) Co., Ltd. was established in 2013. It is an innovative country that specializes in research, development, production, sales, and service of analytical instruments and equipment, consumables, and solutions for biomolecules such as genomes and protein groups. high-tech enterprises. At present, the company mainly focuses on the research and development, production, and market development of MALDI-TOF protein group identification and analysis products, microbial mass spectrometry systems, and microfluidic chip nucleic acid rapid analyzers.
The mass spectrometer is based on the principle that charged particles can be deflected in the electromagnetic field, and separates and detects the composition of substances by the mass difference of the substance of atoms, molecules or molecules. After years of development, the matrix-assisted laser desorption ionization and time-of-flight mass spectrometry (MALDI-TOF) platform has become a widely used biomolecule detection method.
However, at present, the mainstream MALDI-TOF MS technology in the world is still in the qualitative analysis stage, and quantitative analysis is still difficult. On the one hand, it is due to the inadequacies in instrument design principles and techniques. Sample-target scanning, ion detection, and signal acquisition speed cannot fully cover the sample. The distribution of the high-voltage electric field on the target plate makes the center point of the target sample and the edge of the sample. There are differences in the process of ionization and flight time separation, which greatly reduces the quantitative accuracy of the instrument. On the other hand, the stability and the consumability of the gas laser also reduce the performance of the instrument and increase the maintenance cost.
In the face of difficulties, Rongzhi Biotechnology (Qingdao) Co., Ltd. has collaborated with renowned international mass spectrometry experts and the 2010 American Institute of Mass Spectrometry Award winner Marvin Vestal to develop the next-generation full-spectrum quantitative time-of-flight mass spectrometer.
The full-spectrum quantifiable time-of-flight mass spectrometer uses its newly invented new ion source and detector electrical coupling technology, combined with higher frequency, higher precision semiconductor laser desorption and ionization systems and newly designed hybrid detectors. Through new design concepts and technological innovations, it is the first time in the world to achieve a time-of-flight mass spectrometer that maintains high resolution and sensitivity over the entire mass range and can meet quantitative applications.
Currently, the mass spectrometry imaging system newly launched by Rongzhi Biotechnology (Qingdao) Co., Ltd. has adopted the full-spectrum quantitative time-of-flight mass spectrometer. The mass spectrometer scans and collects the ion information for the defined tissue surface area, including the coordinates of the information collection point, the ion mass ratio generated by each component of the tissue surface, and the intensity information of each component ion.
(Source: Rongzhi Biotechnology (Qingdao) Co., Ltd., Analytical and Testing Encyclopedia, Instrument Information Network)